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2011 Call for projects in the field of viral safety for biological products
   
  » Outcome

5th call for projects, selected projects

The Alliance BioSecure Foundation has been established to improve analysis, understanding and management of public health risk related to current or emerging microbiological agents. The highest priority has been given to research projects aimed at minimizing biological risk form prions. In order to enhance the recent progress made into this field and to give the best chances to leverage promising results, the Foundation has decided this year to focus the call in the two following categories:

  1. Development or validation of methods to detect prions in human or animal biological fluids & organs.
  2. Methods to remove or destroy potential prions contaminants in the production of biological products, or to remove or decontaminate instruments/surfaces.

On the 29 letters of intent received, coming mainly from France, England, Germany and the United States, 14 projects have been selected to submit a full application. At the end of the evaluation process, the Scientific Council selected 10 projects that have been approved by the Board of directors on June 29, 2012.

  1. Projet dPica : The digital prion infectivity and concentration assay

    Investigators:
    Pr. Adriano Aguzzi (PI), MD PhD, Professor and Chairman of the Institute of Neuropathology, University Hospital of Zürich
    Ms. Bei Li, PhD, student
    Dr. Simone Hornemann, PhD, senior scientist

    This project aims at establish a fully automated high-throughput digital prion infectivity and concentration assay (dPICA) based on Poisson distribution model.

    More information »

    Duration: 1 year
    Grant: 30 k€

  2. Projet vCJD/BSE agent detection in plasma

    Investigators:
    Olivier Andreoletti (PI), PhD, Head of TSE Unit, INRA, Ecole Nationale Vétérinaire, Toulouse
    Emmanuel Comoy, PhD, Div. of Prions and Related Diseases, iMETI, CEA Fontenay-aux-Roses
    Vincent Beringue, PhD, Head of the group Prions Infections, INRA, Jouy-en-Josas

    This project, based on the unique assay (PMCA based) developed by INRA, aims to assess the performance of TSE agent in plasma from BSE infected sheep, vCJD infected primates and vCJD patient(s) and to compare to the relative infectious titre of plasma as measured by bioassay in tg Bov mice.

    More information »

    Duration: 18 months
    Grant: 40 K€

  3. Projet Prodec: Probing the decontamination of surgical instruments from human prions by quantitative PMCA

    Investigators:
    Michael Beekes, PhD, Scientific Director and Head of Work Group "Unconventional Pathogens and Their Inactivation" in Division Applied Infection Control and Nosocomial Hygiene at the Robert Koch-Institute, Berlin, Germany

    L’objectif de ce projet est de mettre à disposition une méthode alternative au bioessai pour évaluer l’efficacité de la décontamination d’instruments chirurgicaux, cette méthode est une mise au point de la méthode basée sur la PMCA quantitative).

    More information »

    Duration: 6 months
    Grant: 14,5K€

  4. Projet PReMA : Prion Removal by a Metal-Affinity system

    Investigators:
    Dr.Franco Cardone (PI), PhD, First researcher, Istituto Superiore di Sanità, Roma
    Pr. Maurizio Pocchiari, Director Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Roma
    Dr. Ramona Vinci, Dr Edmondo Campisi, Researchers, ISS, Roma, Roma

    The aim of the project is to exploit the capacity of metals to sequester infectious prions to develop a novel prion removal system to be used during plasma fractionation processes. (More information )

    More information »

    Duration: 1 year
    Grant: 37 K€

  5. Projet PMD-Chip : Diagnostic Chip for early detection of Protein Misfoding Disorders

    Investigators:
    Mrs Christiane SEGARRA and Dr Joliette COSTE, Scientifc direction, EFS Pyrénées-Méditerranée Montpellier
    Dr Nicole Jaffrezic, Pr Abdelhamid ERRACHID and Dr Louis Renaud, Claude Bernard Lyon 1 University
    M. Sungmin Kang and M. Kuntaek Lim, PeopleBio, and Pr Seong Soo A. Department of Bionano Technology, Gachon University, South Korea
    Dr Audrey Gabelle-Deloustal, Department of Neurology, Gui de Chauliac Montpellier Hospital

    The aim of the study is to develop a simple and rapid sensitive diagnostic assay allowing early detection in blood of these neurodegenerative disorders. This new test is based on the combination of two innovative technologies: a Multimer Detection System which can differentiate multimers (abnormal proteins) from monomers (normal proteins) by means of specific antibodies and a micro sensor reading system.

    More information »

    Duration: 1 year
    Grant: 35 k€

  6. Projet Prion Blood Confirm Valid : Validation of a PMCA based confirmatory screening assay for the detection of PrPTSE as a marker for vCJD infectivity in human plasma

    Investigators:
    Dr M. Jones (PI), Senior Research Scientist for vCJD Research, Scottish National Blood Transfusion Service, Edinburgh, UK
    Dr J. Coste, Scientific director, EFS Pyrénées-Méditerranée, Montpellier, France
    Dr M. Head, UK National CJD Research and Surveillance Unit), Edinburgh, UK
    Dr V. Béringue: INRA, UR892, Virologie Immunologie Moléculaire, Jouy-en-Josas, France
    Dr A. Perret-Liaudet., Service de Neurobiologie, CHU Lyon
    Dr S. Haik, Centre National de Référence des ATNC , Hôpital de la Salpêtrière, Paris

    The aim of the project is to validate the assay developed previously (collaborative UK and France project funded by Alliance Biosecure based on PMCA) as confirmatory screening assay for the detection of PrPTSE as a marker for vCJD infectivity in human plasma, using the recently issued EU guidelines as a template for the validation process.

    More information »

    Duration: 1 year
    Grant: 30 k€

  7. Projet SurfPMCA : Use of contaminated surfaces as PMCA templates for the evaluation of prion decontamination procedures

    Investigators:
    Prof. Sylvain Lehmann (PI), Head of research group and Dr Carole Crozet, staff scientist, Pathophysiology, diagnosis and cell therapy of neurodegenerative disorders, Institute for Research in Biotherapy, INSERM, CHU Montpellier
    Dr Joliette COSTE, Scientific director and Dr Daisy BOUGARD, EFS Pyrénées-Méditerranée, TransDiag Laboratory
    Dr Vincent Beringue, INRA, UR892, Virologie Immunologie Moléculaire, Jouy-en-Josas, France.

    The aim of this project is to compare the Surf-PMCA detection ( new approach setup with a funded Fabs program based on PMCA which allows the discrimination between none, partially and fully effective treatments using a single wire contaminated with scrapie prion) with reference in vivo animal assays and to adapt it for the test of decontamination of human Prions.

    More information »

    Duration: 1 year
    Grant: 35k€

  8. Projet RTQuIC & E QuIC : Evaluation of the Real Time QuIC and Enhanced QuIC assays for ante-mortem and pre-symptomatic diagnosis of vCJD, sCJD

    Investigators:
    Christina D. Orru` (PI), Ph.D., Team Leader, Department of Biomedical Sciences, University of Cagliari, Italy
    Sarah Vascellari Ph.D., Researcher Fellow and Alessandra Pani Ph.D., Associate Professor, Department of Biomedical Sciences, University of Cagliari, Italy
    Franco Cardone Ph.D., Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Italy
    Byron Caughey Ph.D., Senior Investigator, Laboratory of Persistent Viral Diseases, NIH/NIAID Rocky Mountain Laboratories, USA.

    The aim of the project is to investigate the use of eQuIC assay, combining an immunoprecipitation step with the RT-QuIC creating the Enhanced QuIC which allows to detect low amounts of prions from human, hamster and mouse plasma samples, for early diagnosis of human prion diseases.

    More information »

    Duration: 1 year
    Grant: 40k€

  9. Projet PrP Blood Trap : Development of a diagnosis assay of prions in blood by trapping infectious transient oligomers

    Investigators:
    Dr. Véronique Perrier (PI), Co-Direction of Team 3 in the Inserm U710 Molecular mechanisms in neurodegenerative dementias laboratory, Montpellier
    Dr Joliette Coste, Dr Daisy Bougard and Christiane Segarra, EFS Pyrénées-Méditerranée, Montpellier

    The aim of the project is to adapt our “Rapid centrifugation assay” on blood in order to discriminate normal blood samples from prions-infected ones. This test avoid the proteinase K digestion step and that specifically target those PrPSc dimers and trimers by the use of thienyl pyrimidine (TP) compounds that specifically induce an oligomerization of PrPSc species.

    More information »

    Duration: 18 months
    Grant: 45 k€

  10. Projet MicroRNA profiling : miRNA profiling in blood as a basis for novel diagnostics and early treatment of transmissible spongiform encephalopathies

    Investigators:
    Paula Saá (PI), Transmissible Diseases Department, Holland Laboratory, American Red Cross Head Quarters, Rockville, MD
    Larisa Cervenakova, Jorge De Castro, Oksana Yakovleva, Irina Vasilyeva, American Red Cross
    Neil Renwick, Laboratory of RNA Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York.

    The aim of the project is to obtain miRNAs from blood exosomes of animal models of TSEs to identify biomarkers and PrPTSE by small RNA sequencing and PMCA; a method able to detect minute levels of this disease protein, allowing early diagnosis of TSEs.

    More information »

    Duration: 1 year
    Grant: 20k€
 
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