Risk assessment

Zoo- Scrapie

Permeability of the human species barrier to Scrapie Prions

2014: 2 years / Grant: 60 000 euros

Project: This project aimed to study the transmission barrier of sheep scrapie in humans through transmission of scrapie in transgenic mice carrying human PrP with different polymorphisms, and to characterise the resulting PrPTSE by using several methods: bioassay, PMCA,cellscrapie assay, and culture organotypic assay (COSCA) in order to determine which technique is the most pertinent to address transmission barrier in humans.

Main results and related published data: As this program has only been provided financial support recently, it is too early to present results.