Fundamental research Experimental models


Risk Assessment of iatrogenic transmission of neuro-AMYloidoses.

2008: 1 year / Grant: 70 000 euros

Project: The first objective of the project RAAMY was to evaluate the relationship between A aggregatessize and the capacityto induce a disease such as Alzheimer disease. A second objective was to evaluate iatrogenic transmission as well as some decontamination procedure by using steel wires in prion and Alzheimer’s disease (AD) models.

Main results and related published data: The size distribution of small, soluble oligomers and monomers in AD brains was first studied. For that purpose, MR imaging method (called Gadolinium (Gd) staining) was developed and allowed the visualization of amyloid deposits ex-vivo and in-vivo.
Several mouse models of AD amyloidosisthat develop amyloid plaques, different in size, appearance and composition, were analysed by MRI-Gd. The results were compared to immunohistochemistry for A They observed that depending on the strain, plaques exhibited different aspects by MRI. For the second part, it has not yet been published so that we can not present the results.